New gel effective in treating molluscum contagiosum

Kara Capriotti, MD, reported on a study of patients who were treated with a proprietary low-dose PVP-I/DMSO gel formulation.

The use of povidone-iodine in dimethylsulfoxide gel was effective in treating molluscum contagiosum in a study of 12 patients over eight weeks. The results were presented Saturday during “Late-Breaking Research: Procedural Dermatology” (F073).

Abstract 5227, “Molluscum Contagiosum Treated With Dilute Povidone-Iodine,” reported on the study of patients who were treated with a proprietary low-dose PVP-I/DMSO gel formulation. The study was presented during the session by Kara Capriotti, MD, a dermatologist at Bryn Mawr Skin and Cancer Institute.

“We have found remarkable success with this novel combination that has not been previously reported in the literature, warranting further investigation to elucidate clinical utility,” Dr. Capriotti said. “Our results may have far-reaching impact in dermatology, offering well-tolerated at-home treatment, along with eliminating morbidity from current treatments and frequent office visits.”

Patients in the study were treated with the gel formulation twice a day and evaluated after four weeks. All 12 had complete or partial resolution of the condition. Of 115 lesions treated, 103, or 90 percent, had resolved at eight weeks. Mild skin irritation and dryness were the only adverse effects reported, she said.

Povidone-iodine is a resistance-free, broad-spectrum biocidal agent that eradicates micro-organisms, including bacteria, viruses, yeasts, molds, fungi, and protozoa. Dimethylsulfoxide is an effective vehicle, greatly enhancing percutaneous penetration.

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